I would go with the +Spd-Hp one(Option 2). You want her Defense as high as possible to activate Great Flames effect.
Option 1: +Atk-Def
Option 2: +Spd-Hp
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The second one with Fury can deny a lot of doubles, though that comes at the expense of not running Distant Counter, which people like to do with Myrrh. (It's arguably the best IV, even.)