Medicine Melancholy

Medicine Melancholy was released on May 11th, 2021 as part of the starting roster. For more up-to-date analysis, be sure to visit the  Official Discord Server.

Once a normal doll, Medicine Melancholy was discarded some number of years ago upon the Nameless Hill, surrounded by lily-of-the-valley flowers. Over the years, she became a youkai, who now wishes for the liberation of dolls from humans. Outside of this general disdain for humanity, she has the ability to manipulate poison, thanks to her years of proximity to lily-of-the-valley, which are poisonous. Due to how young she is as a youkai, she does not quite know how to hold back, making her a terrifying foe indeed.

Farming wise, Medicine is unique in that she can Full Break any event stage by herself on the very first hit of her Last Word, allowing her to effectively get 10 DEF DOWN against any stage - though practically speaking she prefers Solo stages, as she has a small but non-negligible chance to fail to Poison all foes in multi-target situations, and her need for three turns (to get both Spirit Power and Accuracy) leaves her too vulnerable to multi-target fights. This is somewhat compromised by her mixed Last Word meaning ATK UP only goes so far for her, alongside her extraordinarily low base ATK values, but it can sometimes let her get the job done. She's also a fantastic option for farming Chapter 2 Act 2's Story Card. 
Solo Stage Farms: 2-7-1 

For harder fights, Medicine is the undisputed queen of Barrier Breaks. Due to the nature of Barrier Anomality breaks, she doesn’t care about Element like most – so long as the enemy isn’t immune to Poison, which is a very small minority of units, she can inflict a ton of Breaks thanks to her All Last Word, Return of Happiness, which has Toxic at merely P0. Unlike Element Breaks, which can only break 1 Barrier per Bullet line, Anomaly Breaks such as Toxic will break all Barriers with the corresponding Anomaly on them. To compliment this, her Skills and Spell Cards apply many layers of Poison onto enemies.

To put it into perspective how much Poison Medicine can apply, without relying on luck: she can Break from 3 to 5 Barriers on one foe, or 1 to 3 to multiple foes. If you’re willing to retry a fight a few times, she can even break up to 8 Barriers on one foe, or 6 on multiple foes – enough to Full Break most enemies immediately! If that’s not enough, she has pretty good access to Wood Element attacks. If you're truly desperate, she even has a single Earth Break at P3 on her second shot, Black Bile.

Medicine is somewhat lacking outside of this, having low damage and no other buffs or debuffs for her team. But her ability to Full Break entire enemy teams single-handedly is enough to make her a devastatingly strong unit in strong fights anyway, thanks to the sheer power of Full Break.

Overall, Medicine is an extremely powerful Friend. You won’t get a ton of use for her in Events, but when it comes to farming the Chapter 1 Boss and Breaking foes in hard fights, she’s second to none. Just make sure not to inhale the poison, she doesn’t know how to hold back.

Here are the chances for Medicine’s secondary effects:

Black Bile: Chance for Poison 0%/0%/0%/0%/0%/30%